Cross Anchor is a Census-designated place in Spartanburg County, South Carolina, United States. The population in the 2010 United States Census was 126.A post office called Cross Anchor has been in operation since 1809. Cross Anchor was named from an old tavern sign depicting two anchors crossed.The Musgrove Mill State Historic Site was listed on the National Register of Historic Places in 1975.Cross Anchor is located in extreme southern Spartanburg County in the Upstate region of South Carolina. The central location is the intersection of South Carolina Highways 49 and 56 where one traffic light exists. Nearby towns include Woodruff, Clinton, Union, and Pauline. Interstate 26 allows for easy access to the north, Spartanburg, and the capital to the south, Columbia.The elevation is 679 feet above mean sea level.